| 英文名稱 | Anti-ANPEN/CD13（Aminopeptidase N） | | 中文名稱 | 氨肽酶N抗體 | | | | | 產(chǎn)品類別 | 兔抗人、大、小鼠CD13抗體 | | 產(chǎn)品價格 | 0.2ml/680元 | | 產(chǎn)品標(biāo)準(zhǔn) | 濃縮液（1mg/1ml） 親和純化抗體 | | 產(chǎn)品應(yīng)用 | WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蠟切片需做抗原修復(fù)） | | 產(chǎn)品介紹 |
氨肽酶N（又稱CD13）是氨肽酶系列的一種，氨肽酶是從蛋白質(zhì)多肽鏈氨基端催化降解氨基酸殘基的水解蛋白酶。是多種冠狀病毒的受體，目前在腫瘤侵襲、轉(zhuǎn)移、免疫調(diào)節(jié)和病毒感染等多方面受人們的關(guān)注.它在腫瘤細(xì)胞表面高水平表達(dá),對腫瘤細(xì)胞外基底膜起到降解作用引發(fā)腫瘤的侵襲和轉(zhuǎn)移。
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E （HCoV-229E） infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus （HCMV） infection. Expressed in epithelial cells. Belongs to the peptidase M1 family.
Alternate Names:
Aminopeptidase N; Alanyl aminopeptidase; Alanyl membrane aminopeptidase; Aminopeptidase M; Aminopeptidase N; ANPEP; APN; CD 13; CD13 antigen; gp150; hAPN; Lap 1; Lap1; Microsomal; aminopeptidase; Myeloid plasma membrane glycoprotein CD13 ; p150 ; PEPN
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