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    CD141是一種轉(zhuǎn)膜糖蛋白，表達(dá)于許多正常組織中如動(dòng)、靜脈內(nèi)皮細(xì)胞，以及間皮細(xì)胞.

    CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximay 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
         Also known as:
T    hrombomodulin; CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM.