| 英文名稱(chēng) | Anti-CCR-4（C-C chemokine receptor 4） | | 中文名稱(chēng) | 細(xì)胞表面趨化因子受體4抗體 | | | | | 產(chǎn)品類(lèi)別 | 兔抗人、大、小鼠CCR4抗體 | | 產(chǎn)品價(jià)格 | 0.2ml/650元 | | 產(chǎn)品標(biāo)準(zhǔn) | 濃縮液（1mg/1ml） 親和純化抗體 | | 產(chǎn)品應(yīng)用 | WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蠟切片需做抗原修復(fù)） | | 產(chǎn)品介紹 |
趨化因子是當(dāng)今細(xì)胞因子研究領(lǐng)域的熱點(diǎn)之一,它參與多種免疫及炎癥反應(yīng),在感染、腫瘤的生長(zhǎng)與轉(zhuǎn)移、組織修復(fù)及創(chuàng)傷愈合等病理生理過(guò)程中發(fā)揮重要作用.
C-C型趨化因子受體4（CCR4）在Th2細(xì)胞表面有大量表達(dá).CCR4在腫瘤的生長(zhǎng)與轉(zhuǎn)移方面起到一定的作用。
Receptors for the C - C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5 and the Duffy blood group antigen. The C - C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR4 is preferentially expressed on type 2 helper T （Th2-type） cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Also named as C C chemokine receptor type 4 ; C C CKR 4 ; CC CKR 4 ; CCR 4 ; Chemokine （CC motif） receptor 4 ; chemokine C C motif receptor 4 ; ChemR13; CKR4; CMKBR 4; CMKBR4; HGCN 14099; K5 5; MGC88293.
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