| 英文名稱 | Anti-BMP2 （bone morphogenetic protein 2） | | 中文名稱 | 骨形態(tài)發(fā)生蛋白-2抗體 | | | | | 產(chǎn)品類別 | 兔抗人、大、小鼠BMP-2抗體 | | 產(chǎn)品價格 | 0.1ml/480元 0.2ml/650元 | | 產(chǎn)品標(biāo)準(zhǔn) | 濃縮液（1mg/1ml） 親和純化抗體 | | 產(chǎn)品應(yīng)用 | WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蠟切片需做抗原修復(fù)） | | 產(chǎn)品介紹 | 神經(jīng)干細(xì)胞標(biāo)志物
BMP-2主要對未分化間充質(zhì)細(xì)胞和骨系細(xì)胞起到募集和分化作用。在骨形成早期，BMP-2不僅可使未分化間質(zhì)細(xì)胞向骨形成中心募集，并分化為骨系細(xì)胞，而且可使成纖維細(xì)胞、成肌細(xì)胞及骨髓的基細(xì)胞逆轉(zhuǎn)分化為骨系細(xì)胞。其主要過程是：增加或抑制這些細(xì)胞內(nèi)的某些特異性蛋白的分泌，使成纖維細(xì)胞分化為成骨細(xì)胞，成肌細(xì)胞快速分化為肥大的軟骨細(xì)胞，并促進(jìn)基質(zhì)鈣化。
對于成骨細(xì)胞，BMP-2則可使之維持其*細(xì)胞表型，并誘導(dǎo)成骨細(xì)胞標(biāo)志物的增高，促進(jìn)細(xì)胞外基質(zhì)鈣化。在骨形成后期，BMP-2還作為一種破骨細(xì)胞分化因子與其它支持破骨細(xì)胞分化因子直接或間接刺激破骨細(xì)胞分化，參與骨的重建。
BMP2 belongs to the transforming growth factor-beta （TGFB） superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis.
Also known as:
bone morphogenetic protein 2； BMP 2; BMP 2A; BMP2; BMP2A .
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