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    是活性氧自由基（ROS）引起DNA氧化損傷修飾產(chǎn)物之一,其生成原因很多,主要是電離輻射、化學(xué)致癌物代謝活化及細(xì)胞正常新陳代謝過程產(chǎn)生大量ROS直接攻擊DNA中的鳥嘌呤（dG）,使脫氧鳥苷氧化為8-OHdG。目前已成為DNA氧化損傷中zui常采用的生物標(biāo)志物。
    8-Hydroxydeoxyguanosine （8OHdG） is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.
    8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine, and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress. Industrial uses may extend to the dietary supplement manufacturers, who could benefit from an immunoassay that could be used to test the effectiveness of antioxidants and other nutraceuticals.
    CHEMICON's new goat antiserum to 8-hydroxyguanosine is now available. This antiserum has been shown by ELISA to be compley cross-reactive with 8-hydroxydeoxyguanosine while not cross-reacting with other naturally occurring nucleotides. This antibody should be a valuable tool for scientists working to understand the role of free radical damage in a number of human disease states.